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Title 

Cytotoxic constituents from Angelicae Sinensis Radix

Authors 

Q C ChenJ P LeeWenYi JinU J YounH J KimI S LeeX F ZhangK S SongY H SeongK H Bae

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2007

Citation 

Archives of Pharmacal Research, vol. 30, no. 5, pp. 565-569

Keywords 

angelicae sinensis radixcytotoxicityneodiligustilideangelica sinensis

Abstract 

Cytotoxic bioassay-guided fractionation of methanol extract of Angelicae Sinensis Radix led to the isolation of a new dimeric Z-ligustilide, named neodiligustilide (1), together with three known compounds, Z-ligustilide (2), 11(S),16(R)-dihydroxy-octadeca-9Z,17-dien-12,14-diyn-1-yl acetate (3), and 3(R),8(S)-falcarindiol (4). Among them, 2 showed the strongest cytotoxicity against L1210 and K562 cell lines with IC50 values of 2.27 ± 0.10 and 4.78 ± 0.18 μM, respectively, while 1 showed moderate cytotoxicity with IC50 values of 5.45 ± 0.19 and 9.87 ± 0.14 μM. Two polyacetylenes, 3 and 4, showed cytotoxicity only against L1210 cell line with IC50 values of 2.60 ± 0.90 and 2.87 ± 0.49 μM, respectively.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02977650

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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