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Title 

Stable transcriptional status in the apoptotic erythroid genome

Authors 

S LeeJ HwangJ UlaszekY C KimH DongH S KimJ W SeokB K SuhS J YimD JohnsonN H ChoeKyu Tae ChangZ Y RyooC C TsengA WickremaS M Wang

Publisher 

Elsevier

Issue Date 

2007

Citation 

Biochemical and Biophysical Research Communications, vol. 359, no. 3, pp. 556-562

Keywords 

apoptosiserythroidgene expressiongenomeSAGEtranscriptionerythroid cellgenome analysiserythroid cellsgenome, human

Abstract 

When a cell is destined for apoptosis, will its genome reprogram its transcriptional machinery to overcome the life-threatening challenge? To address this issue, we performed a genome-wide transcriptome analysis in EPO (erythropoietin) deprivation-induced apoptotic erythroid cells using the SAGE method. The results show that the transcript contents for the majority of the genes remain unchanged in the apoptotic cells, including the apoptotic genes and the heat shock genes. of the small number of genes with an altered expression, they are mainly associated with cellular structure. Our study reveals that there is no genetic reprogramming for the transcriptional machinery in the apoptotic genome. Apoptosis, as defined by programmed cell death, is not a crisis but a peaceful physiological process.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2007.05.168

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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