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Title 

Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B

Authors 

Min Kyun NaDuc Manh HoangD NjamenJ T MbaforZ T FomumP T ThuongJong Seog AhnWon Keun Oh

Publisher 

Elsevier

Issue Date 

2007

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 14, pp. 3868-3871

Keywords 

2-Arylbenzofuran derivativeserythrina addisoniaeprenyl groupprotein tyrosine phosphatase-1B (PTP1B)2 (2' methoxy 4' hydroxyphenyl) 5 (3 methylbut 2 enyl) 6 hydroxybenzofuran2 [2' methoxy 4' hydroxy 5' (3 methylbut 2 enyl)phenyl] 6 hydroxybenzofuran2 [2',4' dihydroxy 3' (3 methylbut 2 enyl)phenyl] 6 hydroxybenzofuranerythrina addisoniae extracterythrina extractprotein tyrosine phosphatase 1B

Abstract 

Bioassay-guided fractionation of an EtOAc-soluble extract of the stem bark of Erythrina addisoniae (Leguminosae), using an in vitro PTP1B inhibitory assay, resulted in the isolation of three new (1-3) and three known (4-6) 2-arylbenzofuran derivatives. The new compounds were identified as 2-[2′,4′-dihydroxy-3′-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (1), 2-[2′-methoxy-4′-hydroxy-5′-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (2), and 2-(2′-methoxy-4′-hydroxyphenyl)-5-(3-methylbut-2-enyl)-6-hydroxybenzofuran (3). The new 2-arylbenzofurans 1-3 inhibited PTP1B activity with IC50 values ranging from 13.6 ± 1.1 to 17.5 ± 1.2 μM in vitro assay. On the basis of the data obtained, 2-arylbenzofurans with prenyl group may be considered as a new class of PTP1B inhibitors.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2007.05.005

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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