상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Lignans and coumarins from the roots of Anthriscus sylvestris and their increase of Caspase-3 activity in HL-60 cells

Authors 

G S JeongOk-Kyoung KwonBo-Young ParkSei Ryang OhKyung Seop AhnM J ChangW K OhJ C KimB S MinY C KimHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2007

Citation 

Biological & Pharmaceutical Bulletin, vol. 30, no. 7, pp. 1340-1343

Keywords 

anthriscus sylvestrisapoptosiscaspase-3DNA fragmentationsylvestrinumbelliferae

Abstract 

A new lignan, sylvestrin (1), was isolated from the MeOH-soluble fraction of the roots of Anthriscus sylvestris HOFFM. (Umbelliferae), along with six lignans (2-7), three coumarins (8-10), and a polyacetylene (11). The structure of sylvestrin was determined to be 2-(3′,4′,5′- trimethoxybenzylidene)-3-(3″,4″-methylendioxybenzyl) -γ-butyrolactone (1) by spectroscopic means, including 2D-NMR. The eleven compounds were assessed for their abilities to activate a caspase-3 in human promyeloid leukemic HL-60 cells. The intracellular caspase-3 activity of (-)-deoxypodophyllotoxin (3), angeloyl podophyllotoxin (5), deoxypicropodophyllin (6), picropodophyllotoxin (7), and falcarindiol (11) increased approximately 4.6, 3.6, 3.7, 3.9, and 3.9-fold, at 0.001, 1, 1, 1, and 20 μM, respectively, over that of the untreated control. In addition, compounds 3, 5, 6, and 7 showed apoptosis-inducing activities that were measured by DNA fragmentation in HL-60 cells.

ISSN 

0918-6158

Link 

http://doi.org/10.1248/bpb.30.1340

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


Files in This Item: SizeFormat
7093.pdf254KbAdobe PDF
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)