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Title 

Polyketides from a sponge-derived fungus, Aspergillus versicolor

Authors 

Y M LeeT A MansoorJ HongC O LeeKyung Sook BaeJ H Jung

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2007

Citation 

Natural Products Sciences, vol. 13, no. 1, pp. 90-96

Keywords 

aspergillus versicolordecumbenones A and Bpetrosia sp.polyketidesponge-derived fungiversioldecumbenone aantibacterial activityaspergillusdrug isolation

Abstract 

Bioactivity guided fractionation of the cultured filtrates of Aspergillus versicolor, which was derived from a marine sponge Petrosia sp., yielded three polyketides: decumbenones A (1), B (2), and versiol (3). These compounds were identified on the basis of 1D and 2D NMR spectroscopic and MS analysis. The absolute configuration was defined by the modified Mosher's method. The isolated compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines and antibacterial activity against twenty clinically isolated methicillin-resistant strains. This is the first report on the isolation of these compounds from a marine source.

ISSN 

1226-3907

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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