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Title 

A statistical analysis of SNPs, In-Dels, and their flanking sequences in human genomic regions

Authors 

S W ShinYoung Joo KimB D Kim

Publisher 

Korea Genome Organization

Issue Date 

2007

Citation 

Genomics & Informatics, vol. 5, no. 2, pp. 68-76

Keywords 

single nucleotide polymorphismsSNPsintronMarkov chain

Abstract 

Due to the increasing interest in SNPs and mutational hot spots for disease traits, it is becoming more important to define and understand the relationship between SNPs and their flanking sequences. To study the effects of flanking sequences on SNPs, statistical approaches are necessary to assess bias in SNP data. In this study we mainly applied Markov chains for SNP sequences, particularly those located in intronic regions, and for analysis of in-del data. All of the pertaining sequences showed a significant tendency to generate particular SNP types. Most sequences flanking SNPs had lower complexities than average sequences, and some of them were associated with microsatellites. Moreover, many Alu repeats were found in the flanking sequences. We observed an elevated frequency of single-base-pair repeat-like sequences, mirror repeats, and palindromes in the SNP flanking sequence data. Alu repeats are hypothesized to be associated with C-to-T transition mutations or A-to-l RNA editing. In particular, the in-del data revealed an association between particular changes such as palindromes or mirror repeats. Results indicate that the mechanism of induction of in-del transitions is probably very different from that which is responsible for other SNPs. From a statistical perspective, frequent DNA lesions in some regions probably have effects on the occurrence of SNPs.

ISSN 

1598-866X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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