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Title 

Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1

Authors 

N T DatX JinJ H LeeD LeeYoung-Soo HongKyeong LeeY H KimJung Joon Lee

Publisher 

American Chemical Society

Issue Date 

2007

Citation 

Journal of Natural Products, vol. 70, no. 7, pp. 1093-1097

Keywords 

abietane derivativehypoxia inducible factor 1drug inhibitionsalvia miltiorrhizaditerpenes, abietanehypoxia-inducible factor 1

Abstract 

The hypoxia-inducible factor-1 (HIF-1) has been known to be correlated to the adaptation and proliferation of tumor cells; therefore HIF-1 has become an important target in the development of anticancer drugs. A phytochemical study of the CHCl3-soluble fraction of Salvia miltiorrhiza, which strongly inhibited hypoxia-induced reporter gene expression, led to the isolation of 12 abietane-type diterpenes. of these compounds, sibiriquinone A (1), sibiriquinone B (2), cryptotanshinone (3), and dihydrotanshinone I (4) potently inhibited hypoxia-induced luciferase expression with IC50 values of 0.34, 3.36, 1.58, and 2.05 μM on AGS cells, a human gastric cancer cell line, and 0.28, 3.18, 1.36, and 2.29 μM on Hep3B cells, a human hepatocarcinoma cell line, respectively. Consistently, 1 and 4 dose-dependently suppressed the HIF-1α accumulation and 1 inhibited mRNA expression of vascular endothelial growth factor (VEGF) under hypoxia. These results suggest that the anticancer activity of tanshinones is likely at least in part associated with their inhibition of HIF-1 accumulation.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np060482d

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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