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Title 

The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice

Authors 

U J JungN I BaekH G ChungM H BangJ S YooTae Sook JeongK T LeeY J KangM K LeeH J KimJ Y YeoM S Choi

Publisher 

Elsevier

Issue Date 

2007

Citation 

Food and Chemical Toxicology, vol. 45, no. 10, pp. 2022-2029

Keywords 

artemisia princeps pampaniniC57BL/KsJ-db/db miceglucose regulating enzymesglucose toleranceinsulin toleranceantidiabetic agentartemisia princeps extractplant extractartemisiaC57BL mouse

Abstract 

The anti-diabetic effects of two variants of Artemisia princeps Pampanini, sajabalssuk (SB) and sajuarissuk (SS), were investigated in type 2 diabetic animal using their ethanol extracts. Male C57BL/KsJ-db/db (db/db) mice were divided into control, SB ethanol extract (SBE), SS ethanol extract (SSE), or rosiglitazone (RG) groups and their age-matched littermates (db/+) were used. Supplementation of the SBE (0.171 g/100 g diet), SSE (0.154 g/100 g diet), and RG (0.005 g/100 g diet) improved glucose and insulin tolerance and significantly lowered blood glycosylated hemoglobin levels, as compared to the control group. Plasma insulin, C-peptide and glucagon levels in db/db mice were higher in the db/+ mice, however these values were significantly lowered by SBE, SSE or RG-supplement. Hepatic GK activity was significantly lower in the db/db mice than in the db/+ mice, while hepatic G6Pase activity was vice versa. Supplementation of SBE, SSE and RG reversed these hepatic glucose-regulating enzyme activities. In addition, SBE and SSE markedly increased the hepatic glycogen content and muscle ratio as compared to the control group, but they did not alter the food intake, body weight and plasma leptin level. The RG group, however, showed a significant increase in the food intake, body weight and plasma leptin. These results suggest that SBE and SSE exert an anti-diabetic effect in type 2 diabetic mice.

ISSN 

0278-6915

Link 

http://dx.doi.org/10.1016/j.fct.2007.04.021

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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