상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor γ (PPARγ) agonists

Authors 

J H AhnM S ShinS H JungJ A KimH M KimS H KimS K KangK R KimS D RheeS D ParkJ M LeeJeong-Hyung LeeH G CheonS S Kim

Publisher 

Elsevier

Issue Date 

2007

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 18, pp. 5239-5244

Keywords 

diabetesindene N-oxidePPARγindene derivativeindene n oxide derivativeperoxisome proliferator activated receptor gamma agonistpioglitazonerosiglitazoneadipogenesiscontrolled study

Abstract 

A series of novel indene N-oxide derivatives were prepared by various synthetic methods and evaluated for their ability to activate PPARγ. The best PPARγ agonist in this series was 9 h, which showed an EC50 value of 15 nM.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2007.06.073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)