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Title 

Anti-inflammatory and anti-allergic effects of kefir in a mouse asthma model

Authors 

Mee Young LeeKyung Seop AhnOk Kyung KwonM J KimM K KimI Y LeeSei Ryang OhHyeong Kyu Lee

Publisher 

Elsevier

Issue Date 

2007

Citation 

Immunobiology, vol. 212, no. 8, pp. 647-654

Keywords 

airway hyper-responsivenessasthmainflammationkefirmucus hyper-secretionovalbumin-induced mouse modelmethacholineovalbuminprobiotic agentallergic asthma

Abstract 

Kefir is a microbial symbiont mixture that produces jelly-like grains. As a widely used neutraceutical, however, the therapeutic applicabilityof kefir is not certain. In order to investigate the pharmacological effects of kefir, we used a mouse asthma model, in which airway inflammation and airway remodeling was produced by ovalbumin sensitization and challenge. BALB/c mice sensitized and challenged to ovalbumin, were treated with kefir (50 mg/kg administered by intra-gastric mode) 1 h before the ovalbumin challenge. Kefir significantly suppressed ovalbumin-induced airway hyper-responsiveness (AHR) to inhaled methacholine. Intra-gastric administration of kefir significantly inhibited the increase in the total inflammatory cell count induced by ovalbumin, and the eosinophil count in bronchoalveolar lavage fluid (BALF). Type 2 helper T cell (Th2) cytokines, such as interleukin-4 and interleukin-13, and total immunoglobulin E (Ig E) levels, were also reduced to normal levels in bronchoalveolar lavage fluid. Histological studies demonstrate that kefir substantially inhibited ovalbumin-induced eosinophilia in lung tissue and mucus hyper-secretion by goblet cells in the airway. Kefir displayed anti-inflammatory and anti-allergic effects in a mouse asthma model and may possess new therapeutic potential for the treatment of allergic bronchial asthma.

ISSN 

0171-2985

Link 

http://dx.doi.org/10.1016/j.imbio.2007.05.004

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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