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Title 

Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents

 

신남알데하이드 신규 골격의 유도체의 합성 및 항암활성 기전 규명

Authors 

Dae Seop ShinJ KimDong Cho HanKwang Hee SonChang Woo LeeHwan Mook KimS H HongByoung-Mog Kwon

Publisher 

Elsevier

Issue Date 

2007

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 19, pp. 5423-5427

Keywords 

apoptosiscell cyclecinnamaldehydeantineoplastic agentdrug synthesisantineoplastic agents

Abstract 

A series of cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G2/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2007.07.033

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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