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Title 

Ring-opening of oxazolines derived from l-serine: a short and efficient stereoselective synthesis of all four diastereomers of 3-mercaptoaspartic acid derivatives

Authors 

Sang-Hyeup LeeJu Han BokX QiS K KimY S LeeJ Yoon

Publisher 

Elsevier

Issue Date 

2007

Citation 

Tetrahedron Letters, vol. 48, no. 41, pp. 7309-7312

Keywords 

3 mercaptoaspartic acid derivativeaspartic acidaspartic acid derivativeoxazoline 4,5dicarboxylateoxazoline derivativeserinethioacetic acidchemical structurediastereoisomer

Abstract 

Facile methods are described for accessing four diastereomerically pure 3-mercaptoaspartic acid derivative from l-aspartic acid. In our synthesis, ring-opening reactions of oxazoline-4,5-dicarboxylate with thiolacetic acid as well as the stereochemical interconversion of both α- and β-configuration via oxazoline chemistry were utilized as key steps.

ISSN 

0040-4039

Link 

http://dx.doi.org/10.1016/j.tetlet.2007.08.041

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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