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Title 

Protective action of honokiol, administered orally, against oxidative stress in brain of mice challenged with NMDA

Authors 

H S CuiL S HuangD E SokJ ShinByoung-Mog KwonU J YounK Bae

Publisher 

Elsevier

Issue Date 

2007

Citation 

Phytomedicine, vol. 14, no. 10, pp. 696-700

Keywords 

glutathionehonokiollipid peroxidationneuroprotectionNMDAbrain protectionbrain weightinstitute for cancer research mousemouseoxidative stress

Abstract 

Neuroprotective effect of honokiol (HK), orally administered, on oxidative damage in the brain of mice challenged with N-methyl-d-aspartic acid (NMDA) was examined. HK (1-100 mg/kg) was administered to Institute of Cancer Research (ICR) male mice through a gavage for 3 days consecutively, and on the third day, NMDA (150 mg/kg) was intraperitoneally (i.p.) administered. Administration of NMDA, causing a lethality of approximately 60%, resulted in a significant decrease of total glutathione (GSH) level and increase of thiobarbituric acid-reactive substances (TBARS) value in brain tissue. Meanwhile, oral administration of HK (≥3 mg/kg) for 3 days reduced the lethality (60%) in NMDA-treated group to 10% level, and alleviated the behavioral signs of NMDA neurotoxicity. Moreover, HK pretreatment restored the levels of total GSH and TBARS in the brain tissue to control levels (p<0.01). Additionally, GSH peroxidase activity in cytosolic portion of brain homogenate was also restored significantly (p<0.01), whereas GSH reductase activity was not. Separately, compared to vehicle-treated control, no significant changes in body and brain weight were observed in mice administered with HK. Based on these results, oral intake of HK is suggested to prevent oxidative stress in the brain of mice.

ISSN 

0944-7113

Link 

http://dx.doi.org/10.1016/j.phymed.2007.03.005

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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