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Title 

Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring

Authors 

Won Cheol KimJong Suk LeeD LeeX F CaiJ C ShinKyeong LeeC H LeeS RyuS G PaikJung Joon LeeYoung-Soo Hong

Publisher 

Wiley-Blackwell

Issue Date 

2007

Citation 

ChemBioChem, vol. 8, no. 13, pp. 1491-1494

Keywords 

ansamycinantitumor agentsgeldanamycinmutasynthesispolyketidesbenzoquinonerifamycingene disruptiongene mutation

Abstract 

(Chemical Equation Presented) A not so familiar ring. We describe results obtained from a mutasynthetic study based on geldanamycin (1), and demonstrate that this technique can be used to extend the structural diversity of the benzoquinone ring of 1. Our results show that geldanamycin PKS modules tolerate polyketide intermediate chains that bear unnatural benzoate components, and that they extend these structures further to produce mature polyketides (see scheme).

ISSN 

1439-4227

Link 

http://dx.doi.org/10.1002/cbic.200700196

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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