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Title 

The role of Hansenula polymorpha MIG1 homologues in catabolite repression and pexophagy

Authors 

O G StasykT ZutphenHyun Ah KangO V StasykM VeenhuisA A Sibirny

Publisher 

Wiley-Blackwell

Issue Date 

2007

Citation 

FEMS Yeast Research, vol. 7, no. 7, pp. 1103-1113

Keywords 

catabolite repressionhansenula polymorphapexophagytranscriptional repressorsyeastprotein hpmig1gene repression

Abstract 

In the methanol-utilizing yeast Hansenula polymorpha, glucose and ethanol trigger the repression of peroxisomal enzymes at the transcriptional level, and rapid and selective degradation of methanol-induced peroxisomes by means of a process termed pexophagy. In this report we demonstrate that deficiency in the putative H. polymorpha homologues of transcriptional repressors Mig1 (HpMig1 and HpMig2), as well as HpTup1, partially and differentially affects the repression of peroxisomal alcohol oxidase by sugars and ethanol. As reported earlier, deficiency in HpTup1 leads to impairment of glucose- or ethanol-induced macropexophagy. In H. polymorpha mig1mig2 double-deletion cells, macropexophagy was also substantially impaired, whereas micropexophagy became a dominant mode of autophagic degradation. Our findings suggest that homologues of the elements of the Saccharomyces cerevisiae main repression pathway have pleiotropic functions in H. polymorpha.

ISSN 

1567-1356

Link 

http://dx.doi.org/10.1111/j.1567-1364.2007.00286.x

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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