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Title 

Anti-tumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras-dependent pathway

 

GTP-Ras 의존형 경로와 밀접하게 연관되어 있는 천마의 항암활성

Authors 

J C HeoS U WooM SonJ Y ParkWon Sik ChoiKyu Tae ChangSung Uk KimE K YoonY H KimH M ShinS H Lee

Publisher 

Spandidos Publications

Issue Date 

2007

Citation 

Oncology Reports, vol. 18, no. 4, pp. 849-853

Keywords 

collagenhermes antigenlamininmatrigelmessenger RNAplant extractproteoglycanRas proteinRhoA guanine nucleotide binding proteintissue inhibitor of metalloproteinase 2

Abstract 

Gastrodia elata Blume (GEB) is an important medicinal plant in Korea. In order to confirm the anti-tumor activities of GEB extracts, we carried out various in vitro anti-tumor assays, including a wound assay and an invasion assay using an ethyl ether extract of GEB. The results showed that the GEB extract exhibits potent anti-tumor activity in vitro in a dose-dependent manner. The expression of CD44, cdc42, Timp-2 or RhoA mRNA did not change by GEB treatment, compared to that of the control. GTP-Ras, an active form of a G-coupled protein family, however, is associated with the anti-tumor activity of GEB extracts. We examined various molecular markers related to metastasis by reverse transcriptase-polymerase chain reaction with the extract of GEB-treated B16 cells. There was an increase in GTP-Ras expression by the Gastrodia elata Blume extract. Together, these results suggest that the Gastrodia elata Blume extract could have potential in alleviating tumorigenesis, by a GTP-Ras-dependent pathway; although the precise molecular mechanisms are still being examined.

ISSN 

1021-335X

Link 

http://dx.doi.org/10.3892/or.18.4.849

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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