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Title 

In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development

Authors 

Y YanSung Sup ParkS JanzL A Eckhardt

Publisher 

Wiley-Blackwell

Issue Date 

2007

Citation 

Genes, Chromosomes & Cancer, vol. 46, no. 10, pp. 950-959

Keywords 

immunoglobulin heavy chain3' untranslated regionanimal cellanimal tissueB cell lymphomaB lymphocytebone marrow cellburkitt lymphomacell compartmentalizationcell lineage

Abstract 

Reciprocal translocations involving the immunoglobulin loci and the cellular oncogene MYC are hallmark mutations of the human postgerminal center B cell neoplasm, Burkitt's lymphoma. They are occasionally found in other B cell lymphomas, as well. Translocations involving the hea\y chain locus (IGH) place the MYC gene either in cis with both the intronic enhancer Eμ and the IGH 3′ regulatory region (3′RR) or in cis with only the 3′RR. The result is deregulated MYC expression. Recent studies have led to some controversy as to when, during B lymphocyte development, IGH/MYC chromosome translocations take place. A related issue, relevant not only to lymphoma development but also to normal controls on IGH gene expression, is the stage, during B lymphocyte development, at which the 3′RR is capable of activating MYC expression. We have developed mice transgenic for a human MYC (hMYC) gene under control of the four core enhancers from the mouse Igh 3′RR. Unlike other transgenic mouse models where premature and inappropriate MYC expression disrupts normal B cell development, the hMYC transgene in these studies carries a mutation that prohibits MYC protein synthesis. As a result, hMYC expression can be analyzed in all of the normal B cell compartments. Our data show that hMYC is expressed almost exclusively in B-lineage cells and is induced to high levels as soon as bone marrow cells reach the immature B cell stage.

Citation 

Genes, Chromosomes & Cancer, 46(10): 950-959

ISSN 

1045-2257

Link 

http://dx.doi.org/10.1002/gcc.20480

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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