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Title 

Hydroxylated hydrocinnamides as hypocholesterolemic agents

Authors 

Sangku LeeChul Ho LeeE KimS H JungHyeong Kyu Lee

Publisher 

The Korean Chemical Society

Issue Date 

2007

Citation 

Bulletin of the Korean Chemical Society, vol. 28, no. 10, pp. 1787-1791

Keywords 

amino acidcinnamic acidhydrocinnamidehypocholesterolemic activityhydroxylated hydrocinnamideshypocholesterolemic agents

Abstract 

Several hydroxylated cinnamic acid derivatives were prepared from the corresponding acids and amino acid residues, and their hypocholesterolemic activities were evaluated in high cholesterol-fed mice. The presence of the double bond in hydroxylated cinnamide derivatives decreases cholesterol-lowering activities and the number of free phenolic hydroxy groups affect greatly the activities. 3,4-Dihydroxy hydrocinnamides obtained from amino acid derivatives containing a hydrophobic side chain such as alanine, valine, phenylalanine, and isoleucine exhibited potent cholesterol-lowering activities.

ISSN 

0253-2964

Link 

http://dx.doi.org/10.5012/bkcs.2007.28.10.1787

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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