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Title 

Macrolactins O-R, glycosylated 24-membered lactones from Bacillus sp. AH159-1

Authors 

C J ZhengSangku LeeC H LeeWon Gon Kim

Publisher 

American Chemical Society

Issue Date 

2007

Citation 

Journal of Natural Products, vol. 70, no. 10, pp. 1632-1635

Keywords 

lactone derivativemacrolactin bmacrolactin cmacrolactin Omacrolactin Pmacrolactin Qmacrolactin Rantibacterial activitybacillus subtiliscontrolled study

Abstract 

In the course of screening for inhibitors of Staphylococcus aureus peptide deformylase, four new glycosylated macrolactin compounds, macrolactins O (1), P (2), Q (3), and R (4), along with the known macrolactins B (5) and C (6), have been isolated from the liquid cultures of Bacillus sp. AH159-1. The structures of compounds 1-4 were assigned on the basis of MS and NMR data. They inhibited S. aureus peptide deformylase and also showed antibacterial activity against Escherichia coli and Staphylococcus aureus.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np0701327

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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