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Title 

Cyclo(dehydroshistidyl-L-tryptophyl), an inhibitor of nitric oxide production from a fungal strain, Fb956

Authors 

H J NohMi Jin SohnHyung Eun YuIck Dong YooWon Gon Kim

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2007

Citation 

Journal of Microbiology and Biotechnology, vol. 17, no. 10, pp. 1717-1720

Keywords 

cyclic peptidecyclo(dehydrohistidyl-L-tryptophyl)microglianitric oxideanimal celldrug activityfungal strainnonhumannuclear magnetic resonance spectroscopy

Abstract 

In the course of screening for nitric oxide inhibitors in activated microglial BV-2 cells, cyclo(dehydrohistidyl-L-tryptophyl) was isolated from solid-state fermentation cultures of an unidentified fungal strain, Fb956. Its structure was determined by spectroscopic methods including 2D NMR and chiral TLC analyses. Cyclo(dehydrohistidyl-L-tryptophyl) was found to have an inhibitory activity on nitric oxide production with an IC50 of 6.5 μM in activated BV-2 cells. The structure determination and biological activity of cyclo (dehydrohistidyl-L-tryptophyl) was reported for the first time in this study.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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