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Title | Cyclo(dehydroshistidyl-L-tryptophyl), an inhibitor of nitric oxide production from a fungal strain, Fb956 |
Authors | H J Noh; Mi Jin Sohn; Hyung Eun Yu; Ick Dong Yoo; Won Gon Kim |
Publisher | The Korean Society for Applied Microbiology |
Issue Date | 2007 |
Citation | Journal of Microbiology and Biotechnology, vol. 17, no. 10, pp. 1717-1720 |
Keywords | cyclic peptide; cyclo(dehydrohistidyl-L-tryptophyl); microglia; nitric oxide; animal cell; drug activity; fungal strain; nonhuman; nuclear magnetic resonance spectroscopy |
Abstract | In the course of screening for nitric oxide inhibitors in activated microglial BV-2 cells, cyclo(dehydrohistidyl-L-tryptophyl) was isolated from solid-state fermentation cultures of an unidentified fungal strain, Fb956. Its structure was determined by spectroscopic methods including 2D NMR and chiral TLC analyses. Cyclo(dehydrohistidyl-L-tryptophyl) was found to have an inhibitory activity on nitric oxide production with an IC50 of 6.5 μM in activated BV-2 cells. The structure determination and biological activity of cyclo (dehydrohistidyl-L-tryptophyl) was reported for the first time in this study. |
ISSN | 1017-7825 |
Appears in Collections | |
Registered Date |
2019-05-02 |
