상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Meta- and gene set analysis of stomach cancer gene expression data

Authors 

Seon-Young KimJeong Hwan KimH S LeeS M NohK S SongJ S ChoH Y JeongW H KimYoung Il YeomNam-Soon KimS KimHyang Sook YooYong Sung Kim

Publisher 

Springer Verlag (Germany)

Issue Date 

2007

Citation 

Molecules and Cells, vol. 24, no. 2, pp. 200-209

Keywords 

databasegastric cancergene setmeta-analysismicroarraycancer classificationcancer geneticschromosome analysisfatty acid metabolismgene amplification

Abstract 

We generated gene expression data from the tissues of 50 gastric cancer patients, and applied meta-analysis and gene set analysis to this data and three other stomach cancer gene expression data sets to define the gene expression changes in gastric tumors. By meta-analysis we identified genes consistently changed in gastric carcinomas, while gene set analysis revealed consistently changed biological themes. Genes and gene sets involved in digestion, fatty acid metabolism, and ion transport were consistently down-regulated in gastric carcinomas, while those involved in cellular proliferation, cell cycle, and DNA replication were consistently up-regulated. We also found significant differences between the genes and gene sets expressed in diffuse and intestinal type gastric carcinoma. By gene set analysis of cytogenetic bands, we identified many chromosomal regions with possible gross chromosomal changes (amplifications or deletions). Similar analysis of transcription factor binding sites (TFBSs), revealed transcription factors that may have caused the observed gene expression changes in gastric carcinomas, and we confirmed the overexpression of one of these, E2FI, in many gastric carcinomas by tissue array and immunohistochemistry.

ISSN 

1016-8478

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)