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Title 

Xanthones from Cudrania tricuspidata displaying potent α-glucosidase inhibition

 

꾸지뽕나무로부터 강력한 알파글루코시데이스 억제제인 잔톤화합물의 개발

Authors 

E J SeoM J Curtis-LongB W LeeH Y KimYoung Bae RyuTae Sook JeongWoo Song LeeK H Park

Publisher 

Elsevier

Issue Date 

2007

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 23, pp. 6421-6424

Keywords 

α-glucosidase inhibitioncudrania tricuspidataxanthone1,3,7 trihydroxy 4 (1,1 dimethyl 2 propenyl) 5,6 (2 2 dimethylchromeno)xanthonealpha glucosidasecudratricusxanthone acudratricusxanthone fcudraxanthone dcudraxanthone lcudraxanthone m

Abstract 

We have proven that xanthones 1-8 isolated from the root of C. tricuspidata possess highly potent αα-glucosidase inhibition properties. Compound 1 was identified as a new isoprenylated tetrahydroxy xanthone, 1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)-8-(2-methylbut-3-en-2-yl)-9H-xanthen-9-one (1). These are the first natural xanthones documented to exhibit such inhibition. The IC50 values of compounds 1-8 inhibiting α-glucosidase activity were determined to be up to 16.2 μM. Mechanistic analysis showed the xanthones 1-8 exhibited full mixed inhibition.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2007.10.007

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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