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Title 

Topical application of silymarin reduces chemical-induced irritant contact dermatitis in BALB/c mice

Authors 

M H HanWoon Kee YoonHyunju LeeS B HanKiho LeeSong Kyu ParkK H YangHwan Mook KimJong Soon Kang

Publisher 

Elsevier

Issue Date 

2007

Citation 

International Immunopharmacology, vol. 7, no. 13, pp. 1651-1658

Keywords 

adhesion moleculesirritant contact dermatitisNF-κBsilymarinTNF-α1 chloro 2,4 dinitrobenzenechemokinecroton oilcytokineendothelial leukocyte adhesion molecule 1

Abstract 

Irritant contact dermatitis (ICD) is a non-allergic local inflammatory reaction of a skin and one of the most frequent occupational health problems. Silymarin has been clinically used in Europe for a long time to treat liver diseases and also known to have anti-cancer and anti-inflammatory activities. In the present study, we report that topical application of silymarin reduces chemical-induced ICD. Topical application of 2,4-dinitrochlorobenzene (DNCB) induced an ear swelling in BALB/c mice and silymarin suppressed DNCB-induced increase in ear thickness. Prophylactic and therapeutic application of silymarin showed similar effect on DNCB-induced increase in ear thickness and skin water content. In addition, phobor ester- or croton oil-induced increase in ear thickness was also inhibited by silymarin treatment. Silymarin also blocked neutrophil accumulation into the ear induced by these irritants. Further study demonstrated that DNCB-induced tumor necrosis factor-α (TNF-α) expression in mouse ear was suppressed by silymarin. DNCB-induced expression of KC, one of the main attractors of neutrophil in mice, and adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1) and E-selectin in mouse ear were also inhibited by silymarin. Moreover, TNF-α-induced expression of cytokines, such as TNF-α and IL-1β, and a chemokine, IL-8, were suppressed by silymarin treatment in human keratinocyte cell line, HaCaT. Silymarin also blocked TNF-α- and DNCB-induced NF-κB activation in HaCaT. Collectively, these results demonstrate that topically applied silymarin inhibits chemical-induced ICD in mice and this might be mediated, at least in part, by blocking NF-κB activation and consequently inhibiting the expression of cytokines and adhesion molecules.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2007.08.019

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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