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Title 

Antitumor activity of cytokine-induced killer cells against human lung cancer

Authors 

Hwan Mook KimJ LimSong Kyu ParkJong Soon KangKiho LeeChang Woo LeeKi Hoon LeeM J YunK H YangG HanS W KwonY KimS B Han

Publisher 

Elsevier

Issue Date 

2007

Citation 

International Immunopharmacology, vol. 7, no. 13, pp. 1802-1807

Keywords 

adoptive immunotherapycytokine-induced killer cellslung cancercytokineantineoplastic activitycell therapyhumanhuman cellkiller cell

Abstract 

Lung cancer is the leading cause of cancer-related death among men and women in the world. Despite the aggressive treatment with surgery, radiation and chemotherapy, the long term survival for lung cancer patients remains low. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human lung cancer was evaluated in vitro and in vivo. Although CD3+CD56+ CIK cells were rare in fresh human peripheral blood mononuclear cells, they could expand more than 1000-fold on day 14 in the presence of anti-CD3 antibody plus IL-2. At an effector-target cell ratio of 30:1, CIK cells destroyed 98% of NCI-H460 human lung cancer cells, which was determined by the 51Cr-release assay. In addition, CIK cells at doses of 3 and 30 million cells per mouse inhibited 57% and 77% of NCI-H460 tumor growth in nude mouse xenograft assay, respectively. This study suggests that CD3+CD56+ CIK cells may be used as an adoptive immunotherapy for patients with lung cancer.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2007.08.016

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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