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Title 

Cytotoxicity of triterpenes isolated from Aceriphyllum rossii

Authors 

I LeeJ K YooM NaB S MinJ LeeBong Sik YunW Y JinH KimU YounQ C ChenK S SongY H SeongK Bae

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2007

Citation 

Chemical & Pharmaceutical Bulletin, vol. 55, no. 9, pp. 1376-1378

Keywords 

aceriphyllum rossiicytotoxicitysaxifragaceaetriterpeneaceriphyllum rossii extracttriterpenes

Abstract 

Bioassay-guided fractionation of a MeOH extract of the whole plant of Aceriphyllum rossii (Saxifragaceae) led to the isolation of two new triterpenes, 3 α,23-isopropylidenedioxyolean-12-en-27-oic acid (1) and 23-hydroxy-3-oxoolean-12-en-27-oic acid (2), together with six known triterpenes, 3-oxoolean-12-en-27-oic acid (3), 3 α-hydroxyolean-12-en-27- oic acid (4), β-peltoboykinolic acid (5), aceriphyllic acid A (6), oleanolic acid (7), and gypsogenic acid (8). The structures of these compounds were elucidated on the basis of physicochemical and spectroscopic analyses. These compounds were evaluated for in vitro cytotoxicity against the K562 and HL-60 cell lines. Olean-12-en-27-oic acid derivatives (1-6) exhibited considerable cytotoxicity against K562 and HL-60 cell lines with IC50 values ranging from 12.2 to 28.7 μM and from 12.1 to 25.8 μM, respectively.

ISSN 

0009-2363

Link 

http://dx.doi.org/10.1248/cpb.55.1376

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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