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Title 

Alteration of gene expression pattern in the mouse heart with infarction

Authors 

Jun Kyoung ChoeEun Kyung KimD Y RyuYoung Suk WonOg Sung MoonCheol-Goo HurHyoung-Chin KimB AhnKi Hoan Nam

Publisher 

Korean Association for Laboratory Animal Science

Issue Date 

2007

Citation 

Labolatory Animal Research, vol. 23, no. 3, pp. 317-320

Keywords 

myocardial infactionmicroarraymouse

Abstract 

Myocardial infarction (MI) is one of the leading causes of death in advanced nations. The therapeutic option is limited for chronic heart failure which is the result of MI. Recently, it has been reported that adult cardomyocytes can proliferate although the proliferating ability is quite low. To find clues for efficient induction of myocardial proliferation in heart with MI, we analyzed gene expression pattern in the heart with MI using microarray assay in mice. We found 17 and 8 genes of which the expression level increased and decreased in mouse heart with MI compared with those in normal ones, respectively. These alterations in the gene expressions reflect the heart under healing from MI. Therefore, further analysis for these genetic changes may helpful in future cell-based therapeutic application and induction of myocardial cell proliferation in patients with MI.

ISSN 

1738-6055

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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