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Title 

Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia

Authors 

C Z WuX F CaiN T DatS S HongA R HanE K SeoB Y HwangJ X NanD LeeJung Joon Lee

Publisher 

Elsevier

Issue Date 

2007

Citation 

Tetrahedron Letters, vol. 48, no. 50, pp. 8861-8864

Keywords 

fabaceaehypoxia-inducible factor-1meroterpenoidpsoralea corylifoliabisbakuchiol Abisbakuchiol Bdioxanehypoxia inducible factor 1meroterpenoid derivativeterpenoid derivative

Abstract 

Two novel dimeric meroterpenoids, bisbakuchiols A and B, along with (S)-bakuchiol were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). Bisbakuchiols A and B contain an unprecedented dimeric meroterpenoid skeleton in which two meroterpenes are linked through a dioxane bridge. All compounds were evaluated for their potential to inhibit hypoxia-inducible factor-1 (HIF-1) activation induced by hypoxia in a HIF-1-mediated reporter gene assay in AGS human gastric cancer cells. (S)-Bakuchiol inhibited hypoxic activation of HIF-1 with an IC50 value of 6.1 μM.

ISSN 

0040-4039

Link 

http://dx.doi.org/10.1016/j.tetlet.2007.10.059

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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