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Title 

Harzianums A and B produced by a fungal strain, Hypocrea sp. F000527, and their cytotoxicity against tumor cell lines

Authors 

H Z JinJ H LeeW D ZhangH B LeeYoung-Soo HongY H KimJung Joon Lee

Publisher 

Taylor & Francis

Issue Date 

2007

Citation 

Journal of Asian Natural Products Research, vol. 9, no. 3, pp. 203-207

Keywords 

cytotoxicityharzianum Bhypocrea sptumor cell linesantineoplastic agentdoxorubicinester derivativeharzianum Aplant extractantineoplastic activity

Abstract 

A new compound, harzianum B (1), was isolated from the culture broth of a fungal strain, Hypocrea sp. F000527, together with a known trichothecene, harzianum A (2). Its structure was determined by spectroscopic analyses including HRFAB-MS and various 1H NMR and 13C NMR spectral data. Harzianum B (1) was characterised as (E,Z,E)-2′, 4′, 6′-octatriendioic acid esterified on the 4β-hydroxyl group of trichodermol. Harzianums A (2) and B (1) showed cytotoxicity against several human cancer cell lines.

ISSN 

1028-6020

Link 

http://dx.doi.org/10.1080/10286020500531977

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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