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Title 

High prevalence of RET, RAS, and ERK expression in Hashimoto's thyroiditis and in papillary thyroid carcinoma in the Korean population

Authors 

D Y KangK H KimJ M KimS H KimJ Y KimH W BaikYong Sung Kim

Publisher 

Mary Ann Liebert

Issue Date 

2007

Citation 

Thyroid, vol. 17, no. 11, pp. 1031-1038

Keywords 

boneenzyme inhibitiongrowth kineticsbiochemical engineering1 [[6 (3 methoxyestra 1,3,5(10) trien 17beta yl)amino]hexyl] 1h pyrrole 2,5 dione1 [[6 (3 methoxyestra 1,3,5(10) trien 17beta yl)amino]hexyl] 2,5 pyrrolidinedioneethylene glycol 1,2 bis(2 aminophenyl) ether n,n,n',n' tetraacetic acid acetoxymethyl esterimmunoglobulin enhancer binding proteinmitogen activated protein kinase inhibitorosteoclast differentiation factor

Abstract 

Vascular endothelial growth factor (VEGF) is known as a key regulator of angiogenesis during endochondral bone formation. Recently, we demonstrated that TNF-related activation-induced cytokine (TRANCE or RANKL), which is essential for bone remodeling, also had an angiogenic activity. Here we report that VEGF up-regulates expression of receptor activator of NF-κB (RANK) and increases angiogenic responses of endothelial cells to TRANCE. Treatment of human umbilical vein endothelial cells (HUVECs) with VEGF increased both RANK mRNA and surface protein expression. Although placenta growth factor specific to VEGF receptor-1 had no significant effect on RANK expression, inhibition of downstream signaling molecules of the VEGF receptor-2 (Flk-1/KDR) such as Src, phospholipase C, protein kinase C, and phosphatidylinositol 3′-kinase suppressed VEGF-stimulated RANK expression in HUVECs. Moreover, the MEK inhibitor PD98059 or expression of dominant negative MEK1 inhibited induction of RANK by VEGF but not the Ca2+ chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acidacetoxymethyl ester (BAPTA-AM). VEGF potentiated TRANCE-induced ERK activation and tube formation via RANK up-regulation in HUVECs. Together, these results show that VEGF enhances RANK expression in endothelial cells through Flk-1/KDR-protein kinase C-ERK signaling pathway, suggesting that VEGF plays an important role in modulating the angiogenic action of TRANCE under physiological or pathological conditions.

ISSN 

1050-7256

Link 

http://dx.doi.org/10.1089/thy.2007.0035

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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