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Title 

Antioxidant and antiatherogenic activity of cis-hinokiresinol from Trapa pseudoincisa

Authors 

M C SongH J YangM H BangD K KimTae Sook JeongJong Pyung KimN I Baek

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2007

Citation 

Archives of Pharmacal Research, vol. 30, no. 11, pp. 1392-1397

Keywords 

ABTScis-HinokiresinolhACATLDL-oxidationLp-PLA2superoxidetrapa pseudoincisaantioxidanthinokiresinolantioxidants

Abstract 

cis-Hinokiresinol, also known as (+)-nyasol, was isolated for the first time from an aquatic herbaceous plant, Trapa pseudoincisa NAKAI, via silica gel and octadecyl silica gel column chromatographies. The chemical structure was determined via analyses of the spectroscopic data, including NMR, MS and IR. cis-Hinokiresinol was also found to exhibit antioxidant and antiatherogenic activities. The IC50 values for the scavenging activities of cis-hinokiresinol on ABTS cation and superoxide anion radicals were 45.6 and 40.5 μM, respectively. The IC50 values for the inhibitory effects on Lp-PLA2, hACAT1, hACAT2 and LDL-oxidation were 284.7, 280.6, 398.9 and 5.6 μM, respectively.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02977362

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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