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Title 

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

Authors 

Kyeong LeeJ S RyuY JinWon Cheol KimN KaurSang Jeon ChungY J JeonJ T ParkJ S BangH S LeeT Y KimJung Joon LeeYoung-Soo Hong

Publisher 

Royal Society of Chemistry

Issue Date 

2008

Citation 

Organic & Biomolecular Chemistry, vol. 6, no. 2, pp. 340-348

Keywords 

biosynthesisderivativesmetabolitesanti-proliferation activitygeldanamycinbenzoquinone derivativesynthesis

Abstract 

A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2.

ISSN 

1477-0520

Link 

http://dx.doi.org/10.1039/b713407j

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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