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Title 

Hyaluronic acid induces transglutaminase II to enhance cell motility; role of Rac1 and FAK in the induction of transglutaminase II

Authors 

Y KimYoung Woo ParkY S LeeD Jeong

Publisher 

Springer Verlag (Germany)

Issue Date 

2008

Citation 

Biotechnology Letters, vol. 30, no. 1, pp. 31-39

Keywords 

focal adhesion kinasehyaluronic acidmotilityRac1transglutaminase IIcell deathmelanoma cell motilityRac1 proteinRAC1 protein, humantransglutaminase 2

Abstract 

The role of transglutaminase II (TGase II) in hyaluronic acid (HA)-promoted melanoma cell motility was investigated. HA induced the expression of TGase II via the nuclear factor κB (NF-kB) in melanoma cells. HA increased the Rac1 activity and phosphorylation of focal adhesion kinase (FAK). Transfection by lipofectamine of dominant-negative Rac1, and FAK-related non-kinase (FRNK), an endogenous inhibitor of FAK, suppressed the induction of TGase II. This suggests that Rac1 and FAK mediate induction of TGase II by HA. HA-promoted melanoma cell motility was inhibited by cystamine, an inhibitor of TGase II, and overexpression of TGase II enhanced melanoma cell motility through reactive oxygen species. Taken together, HA promotes melanoma cell motility through activation of Rac1, FAK, and induction of TGase II.

ISSN 

0141-5492

Link 

http://dx.doi.org/10.1007/s10529-007-9496-1

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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