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Title 

Prenylated flavonoids with PTP1B inhibitory activity from the root bark of Erythrina mildbraedii

Authors 

JunPil JangMin Kyun NaP T ThuongD NjamenJ T MbaforZ T FomumE R WooW K Oh

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2008

Citation 

Chemical & Pharmaceutical Bulletin, vol. 56, no. 1, pp. 85-88

Keywords 

erythrina mildbraediileguminosaeprenyl flavonoidprotein tyrosine phosphatase 1B inhibitorerythrina mildbraedii extractflavonoiddrug activityenzyme activitybarkerythrina

Abstract 

Phytochemical study on an EtOAc-soluble extract of the root bark of Erythrina mildbraedii resulted in the isolation of six prenylated flavonoids 1-6. Based on physicochemical and spectroscopic analyses, their structures were determined to be new natural products licoflavanone-4′-O-methyl ether (1), 2′,7-dihydroxy-4′-methoxy-5′-(3-methylbut-2-enyl)isoflavone (2), and (3R)-2′,7-dihydroxy-3′-(3-methylbut-2-enyl)-2?, 2?-dimethylpyrano[5?,6?: 4′,5′]isoflavan (3), along with three known compounds erythrinin B (4), abyssinin II (5), and parvisoflavone B (6). All the isolates, except for compound 4, inhibited PTP1B activity in vitro with IC50 values ranging from 5.3 to 42.6 μM. This result further suggests that the prenyl group on the B ring of flavonoids plays an important role in suppressing the enzyme PTP1B.

ISSN 

0009-2363

Link 

http://dx.doi.org/10.1248/cpb.56.85

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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