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Title 

Clusterin, a novel modulator of TGF-β signaling, is involved in Smad2/3 stability

Authors 

K B LeeJ H JeonIn Pyo ChoiO Y KwonKweon YuK H You

Publisher 

Elsevier

Issue Date 

2008

Citation 

Biochemical and Biophysical Research Communications, vol. 366, no. 4, pp. 905-909

Keywords 

clusterinSmad2Smad3TGF-βSmad2 proteinSmad3 proteinsmall interfering RNAtransforming growth factor betagenetic transcriptionhuman

Abstract 

Clusterin (CLU) is known as a multifunctional protein involved in a variety of physiological processes including lipid transport, epithelial cell differentiation, tumorigenesis, and apoptosis. It is known that CLU interacts with TGF-β type ll receptor (TβRll). However, the relationship of CLU and TGF-β signaling is unclear. Here we present that CLU is a novel modulator of TGF-β signaling by regulating Smad2/3 proteins. Overexpression of CLU enhanced TGF-β-induced transcriptional activity and increased the amount of Smad2/3 proteins, while CLU siRNA repressed TGF-β-induced transcriptional activity and decreased the amount of Smad2/3 proteins in Hep3B cells. We also found that CLU was involved in Smad2/3 stability at the protein level. These findings suggest that CLU regulates TGF-β signaling pathway by modulating the stability of Smad2/3 proteins.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2007.12.033

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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