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Title 

Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice

 

C57BL/KsJ-db/db마우스에서 글루코오스와 지질대사에 있어서 순무 주정추출물의 효과

Authors 

U J JungN I BaekH G ChungM H BangTae Sook JeongK T LeeY J KangM K LeeH J KimJ YeoM S Choi

Publisher 

Elsevier

Issue Date 

2008

Citation 

Clinical Nutrition, vol. 27, no. 1, pp. 158-167

Keywords 

brassica rapaglucose regulating enzymesglucose toleranceinsulin resistancelipid regulating enzymestype 2 diabetesglucoseglucose 6 phosphataseglucose dehydrogenaselipid

Abstract 

Background & aims: The antidiabetic efficacy of turnip (Brassica rapa) roots ethanol extract (TE) was investigated in type 2 diabetic animals. Methods: C57BL/KsJ-db/db (db/db) mice and db/+ mice were used and the db/db mice were divided into control, TE (0.26g/100 g diet) and rosiglitazone (RG, 0.005 g/100 g diet) groups. Results: Despite hyperinsulinemia, the glucokinase activity was lower in the liver of the db/db mice than the db/+ mice, while the glucose-6-phosphatase activity was higher. TE and RG improved the glucose and insulin tolerance and lowered the blood glycosylated hemoglobin, plasma insulin, C-peptide and glucagon levels as well as reversed these hepatic glucose regulating enzyme activities in db/db mice. TE also increased the insulin/glucagon ratio and hepatic glycogen content. The plasma free fatty acid and plasma and hepatic cholesterol and triglyceride levels were higher in the db/db mice than db/+ mice. Interestingly, TE and RG lowered these plasma and hepatic lipids, and simultaneously reduced the hepatic phosphatidate phosphohydrolase, HMG-CoA reductase, ACAT, β-oxidation and carnitine palmitoyl transferase activities. Furthermore, TE lowered the hepatic fatty acid synthase activity, hepatic lipid droplets accumulation, and adipose tissue weight and size. Conclusions: We suggest TE may exert an antidiabetic effect in type 2 diabetic mice by enhancing the glucose and lipid metabolism.

ISSN 

0261-5614

Link 

http://dx.doi.org/10.1016/j.clnu.2007.09.009

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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