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Title 

Hypoxia-induced IL-18 increases hypoxia-inducible factor-1α expression through a Rac1-dependent NF-κB pathway

Authors 

J KimY ShaoS Y KimS KimH K SongJ H JeonHyun Woo SuhJin Woong ChungSuk Ran YoonY S KimIn Pyo Choi

Publisher 

American Society for Cell Biology

Issue Date 

2008

Citation 

Molecular Biology of the Cell, vol. 19, no. 2, pp. 433-444

Keywords 

guanosine triphosphatasehypoxia inducible factor 1alphaimmunoglobulin enhancer binding proteininterleukin 18interleukin 18 receptor betaphosphatidylinositol 3 kinaseprotein kinase BRac1 proteinanimal cellcytokine release

Abstract 

Interleukin-18 (IL-18) plays pivotal roles in linking inflammatory immune responses and tumor progression and metastasis, yet the manner in which this occurs remains to be sufficiently clarified. Here we report that hypoxia induces the transcription and secretion of IL-18, which subsequently induces the expression of hypoxia-inducible factor-1α (HIF-1α). Mechanistically, IL-18 induces HIF-1α through the activity of the GTPase Rac1, which inducibly associates with the IL-18 receptor β (IL-18Rβ) subunit, via a PI3K-AKT-NF-κB-dependent pathway. Importantly, the knockdown of the IL-18Rβ subunit inhibited IL-18-driven tumor cell metastasis. Collectively, these findings demonstrate a feed-forward pathway in HIF-1α-mediated tumor progression, in which the induction of IL-18 by hypoxia or inflammatory cells augments the expression of both HIF-1α and tumor cell metastasis.

ISSN 

1059-1524

Link 

http://dx.doi.org/10.1091/mbc.E07-02-0182

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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