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Title 

Ohioensins F and G: Protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum

Authors 

C SeoY H ChoiJ H SohnJong Seog AhnJ H YimH K LeeH Oh

Publisher 

Elsevier

Issue Date 

2008

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 2, pp. 772-775

Keywords 

benzonaphthoxanthenonesnon-competitive inhibitorpolytrichastrum alpinumprotein tyrosine phosphatase 1B (PTP1B)ohioensin Fohioensin Gprotein tyrosine phosphatase 1Bprotein tyrosine phosphatase 1B inhibitorantarcticadrug isolation

Abstract 

Ohioensins F and G (1 and 2), two new benzonaphthoxanthenones, have been isolated from the MeOH extract of Antarctic moss Polytrichastrum alpinum by various chromatographic methods. The structures of these compounds were determined mainly by analysis of NMR spectroscopic data. The known compounds ohioensins A and C (3 and 4) were also obtained. Compounds 1-4 showed potent inhibitory activity against therapeutically targeted protein tyrosine phosphatase 1B (PTP1B). Kinetic analysis of PTP1B inhibition by ohioensin F (1) suggested that benzonaphthoxanthenones inhibited PTP1B activity in a non-competitive manner.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2007.11.036

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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