상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Effects of a polyacetylene from Panax ginseng on Na+ currents in rat dorsal root ganglion neurons

Authors 

S J ChoiT H KimY K ShinC S LeeM ParkHyun Sun LeeJ H Song

Publisher 

Elsevier

Issue Date 

2008

Citation 

Brain Research, vol. 1191, no. C, pp. 75-83

Keywords 

dorsal root ganglionNa+ currentpanax ginsengpolyacetylenetetrodotoxin-resistanttetrodotoxin-sensitiveepoxyheptadecan 4,6 diyn 3 oneginseng extractheptadecanoic acid

Abstract 

The root of ginseng (Panax ginseng) has been used as a traditional medicine in the far east countries since ancient times. Ginseng extracts produce analgesia among other various biologically beneficial effects. A polyacetylenic compound, (9R,10S)-epoxyheptadecan-4,6-diyn-3-one (EHD), has been isolated from ginseng extract, whose biological activity is largely unknown. Voltage-gated Na+ channels in primary sensory neurons play important roles in pain perception. We investigated the effects of EHD on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na+ currents in acutely dissociated rat dorsal root ganglion neurons. EHD inhibited both Na+ currents in a concentration-dependent manner with an equal potency (Kd values were both 14.3 μM). The activation voltage was not affected by EHD in either type of Na+ current. However, EHD accelerated the inactivation of both Na+ currents and produced a hyperpolarizing shift of the steady-state inactivation curve. In addition EHD suppressed the maximal Na+ current at negative holding potentials at which the channels are relieved from inactivation. Thus EHD appears to bind both resting and inactivated channels. The recovery from inactivation of both Na+ currents was also slowed by EHD. EHD inhibition of TTX-S Na+ current but not TTX-R Na+ current was frequency-dependent. This is the first report that a polyacetylene from ginseng inhibits Na+ currents in primary sensory neurons. EHD by inhibiting Na+ currents may contribute to the ginseng analgesia.

ISSN 

0006-8993

Link 

http://dx.doi.org/10.1016/j.brainres.2007.11.047

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)