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Title 

Farnesyl protein transferase inhibitory components of Lithospermum erythrorhizon

Authors 

S J KimByoung-Mog KwonS H KimN I BaekJ H YangJ J LeeS I LeeY E KwonH W ParkJ H LeeJ S ParkD K Kim

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2007

Citation 

Natural Products Sciences, vol. 13, no. 4, pp. 328-331

Keywords 

boraginaceaeFPTaselithospermum erythrorhizonnaphthoquinonelithospermum extractprotein farnesyltransferaselithospermumprotein analysisprotein isolation

Abstract 

The methanolic extract of the roots of Lithospermum erythrorhizon (Boraginaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three naphthoquinone compounds, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.

ISSN 

1226-3907

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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