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Title 

Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug

Authors 

H Y ParkK S OhH M KooS H ChoSang Jeon ChungYong Taik LimD KimS H Yuk

Publisher 

Informa Healthcare

Issue Date 

2008

Citation 

Journal of Microencapsulation, vol. 25, no. 2, pp. 106-110

Keywords 

heparinmicroparticlepluronicpolyvinylalcoholsustained release of ionic drugdrug delivery systemdrug releasesustained release formulation

Abstract 

Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/ intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC).

ISSN 

0265-2048

Link 

http://dx.doi.org/10.1080/02652040701800917

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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