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Title 

Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides

Authors 

T S KangH O JoW K ParkJong Pyung KimY KonishiJ Y KongN S ParkY S Jung

Publisher 

Elsevier

Issue Date 

2008

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 5, pp. 1663-1667

Keywords 

4-Hydroxycinnamamideantioxidantlipid peroxidationreactive oxygen species3,5 dialkoxy 4 hydroxycinnamamide derivative3,5 dialkoxy 4 hydroxyphenylalkyl amineantioxidant activitydrug synthesisstructure-activity relationship

Abstract 

A series of 3,5-dialkoxy-4-hydroxycinnamamides 6 and 7 was synthesized, and their antioxidant activity was assessed using the thiobarbituric acid reactive substance (TBARS) assay. Interestingly, cinnamamides with longer alkoxy groups on the C-3 and C-5 positions display enhanced inhibition, and most of the compounds in the series tested exhibit excellent lipid peroxidation inhibitory activities. Some cinamamides bearing hexyloxy or 2,6-di-tert-butyl-4-methyl phenol groups have submicromolar inhibitory activities.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2008.01.061

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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