상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

SNP@Promoter: a database of human SNPs (single nucleotide polymorphisms) within the putative promoter regions

Authors 

Byoung Chul KimWoo-Yeon KimDaeui ParkWon Hyong ChungKwang Sig ShinJong Bhak

Publisher 

BioMed Central

Issue Date 

2008

Citation 

BMC Bioinformatics, vol. 9, no. Sup1, pp. S2-S2

Keywords 

transcription factoruntranslated RNAcomputer interfacegenetic databasehumanmedical informationpromoter regiontranscription initiation sitechromosome mapdata base

Abstract 

Background: Analysis of single nucleotide polymorphism (SNP) is becoming a key research in genomics fields. Many functional analyses of SNPs have been carried out for coding regions and splicing sites that can alter proteins and mRNA splicing. However, SNPs in non-coding regulatory regions can also influence important biological regulation. Presently, there are few databases for SNPs in non-coding regulatory regions. Description: We identified 488,452 human SNPs in the putative promoter regions that extended from the +5000 bp to -500 bp region of the transcription start sites. Some SNPs occurring in transcription factor (TF) binding sites were also predicted (47,832 SNP; 9.8%). The result is stored in a database: SNP@promoter. Users can search the SNP@Promoter database using three entries: 1) by SNP identifier (rs number from dbSNP), 2) by gene (gene name, gene symbol, refSeq ID), and 3) by disease term. The SNP@Promoter database provides extensive genetic information and graphical views of queried terms. Conclusion: We present the SNP@Promoter database. It was created in order to predict functional SNPs in putative promoter regions and predicted transcription factor binding sites. SNP@Promoter will help researchers to identify functional SNPs in non-coding regions.

ISSN 

1471-2105

Link 

http://dx.doi.org/10.1186/1471-2105-9-S1-S2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


Files in This Item: SizeFormat
7519.pdf739KbAdobe PDF
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)