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Title 

Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma

Authors 

Hyun Goo WooE S ParkJ H CheonJ H KimJ S LeeB J ParkW KimS C ParkY J ChungB G KimJ H YoonH S LeeC Y KimN J YiK S SuhK U LeeIn-Sun ChuT RoskamsS S ThorgeirssonY J Kim

Publisher 

American Association for Cancer Research

Issue Date 

2008

Citation 

Clinical Cancer Research, vol. 14, no. 7, pp. 2056-2064

Keywords 

cancer recurrencegene expressionhepatitis Bhepatitis B virushumanliver cell carcinomacarcinoma, hepatocellulargene expression profilinghepatitis B, chronic

Abstract 

Purpose: The poor prognosis of hepatocellular carcinoma (HCC) is, inpart, due to the high rate of recurrence even after "curative resection" of tumors. Therefore, it is axiomatic that the development of an effective prognostic prediction model for HCC recurrence after surgery would, at minimum, help to identify in advance those who would most benefit fromthe treatment, and at best, provide new therapeutic strategies for patients with a high riskof early recurrence. Experimental Design: For the prediction of the recurrence time in patients with HCC, gene expression profiles were generated in 65 HCC patients with hepatitis Binfections. Result: Recurrence-associated gene expression signatures successfully discriminated between patients at high-risk and low-risk of early recurrence (P = 1.9 × 10-6, log-rank test). To test the consistency and robustness of the recurrence signature, we validated its prognostic power in an independent HCC microarray data set. CD24 was identified as a putative biomarker for the prediction of early recurrence. Genetic network analysis suggested that SP1 and peroxisome proliferator - activated receptor-α might have regulatory roles for the early recurrence of HCC. Conclusion: We have identified a gene expression signature that effectively predicted early recurrence of HCC independent of microarray platforms and cohorts, and provided novel biological insights into the mechanisms of tumor recurrence.

ISSN 

1078-0432

Link 

http://dx.doi.org/10.1158/1078-0432.CCR-07-1473

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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