상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Sesquiterpene furan compound CJ-01, a novel chitin synthase 2 inhibitor from Chloranthus japonicus SIEB

Authors 

Nam Hui YimE I HwangBong Sik YunK D ParkJae Sun MoonS H LeeN D SungSung Uk Kim

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2008

Citation 

Biological & Pharmaceutical Bulletin, vol. 31, no. 5, pp. 1041-1044

Keywords 

antifungal activitychitin synthase 2 inhibitorchloranthus japonicusfungal cell wallsesquiterpene furan compound CJ-013,4,8a trimethyl 4a,7,8,8a tetrahydro 4a naphto[2,3 b]furan 9 oneantifungal agentcj 01sesquiterpene derivative

Abstract 

A novel sesquiterpene furan compound CJ-01 was isolated from the methanol extract of the whole plant of Chloranthus japonicus SIEB. by monitoring the inhibitory activity of chitin synthase 2 from Saccharomyces cerevisiae. Based on spectroscopic analysis, the structure of compound CJ-01 was determined as 3,4,8a-trimethyl-4a,7,8,8a-tetrahydro-4a-naphto[2,3-b]furan-9-one. The compound inhibited chitin synthase 2 of Saccharomyces cerevisiae in a dose-dependent manner with an IC50 of 39.6 μg/ml, whereas it exhibited no inhibitory activities against chitin synthase 1 and 3 of S. cerevisiae up to 280 μg/ml. CJ-01 has 1.7-fold stronger inhibitory activity than polyoxin D (IC50=70 μg/ml), a well-known chitin synthase inhibitor. These results indicate that the compound is a specific inhibitor of chitin synthase 2 from S. cerevisiae. In addition, CJ-01 showed antifungal activities against various human and phytopathogenic fungi. Therefore, the compound might be an interesting lead to develop effective antifungal agents.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.31.1041

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


Files in This Item: SizeFormat
7561.pdf87KbAdobe PDF
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)