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Title 

Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe

 

Zingiber officinale Roscoe에서 분리한 생리활성 물질

Authors 

J S KimS I LeeH W ParkJ H YangT Y ShinY C KimN I BaekS H KimS U ChoiByoung-Mog KwonK H LeemM Y JungD K Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2008

Citation 

Archives of Pharmacal Research, vol. 31, no. 4, pp. 415-418

Keywords 

cell proliferationcytotoxicitygingerolshogaolzingiber officinalezingiberaceaerhizome

Abstract 

Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53-/-, c-myc, K-ras) and C2 (genotype: p53 -/-, c-myc, Akt), with ED50 values of 0.58 μM (C1) and 10.7 μM (C2).

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-001-1172-y

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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