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Title | In vitro antioxidant and anti-inflammatory activities of Jaceosidin from Artemisia princeps Pampanini cv. Sajabal |
Authors | Min Jung Kim; Jong Min Han; Y Y Jin; N I Baek; M H Bang; H G Chung; M S Choi; K T Lee; D E Sok; Tae Sook Jeong |
Publisher | Pharmaceutical Society of Korea |
Issue Date | 2008 |
Citation | Archives of Pharmacal Research, vol. 31, no. 4, pp. 429-437 |
Keywords | anti-inflammation; antioxidant; artemisia princeps pampanini cv. sajabal; atherosclerosis; jaceosidin; macrophages; antiinflammatory agent; apolipoprotein B100; immunoglobulin enhancer binding protein |
Abstract | Oxidized low-density lipoprotein (oxLDL) plays a key role in the inflammatory processes of atherosclerosis. Jaceosidin isolated from the methanolic extracts of the aerial parts of Artemisia princeps Pampanini cv. Sajabal was tested for antioxidant and anti-inflammatory activities. Jaceosidin inhibited the Cu2+-mediated LDL oxidation with IC50 values of 10.2 μM in the thiobarbituric acid-reactive substances (TBARS) assay as well as the macrophage-mediated LDL oxidation. The antioxidant activities of jaceosidin were exhibited in the conjugated diene production, relative electrophoretic mobility, and apoB-100 fragmentation on copper-mediated LDL oxidation. Jaceosidin also inhibited the generation of reactive oxygen species (ROS) concerning in regulation of NF-κB signaling. And jaceosidin inhibited nuclear factor-kappa B (NF-κB) activity, nitric oxide (NO) production, and suppressed expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. |
ISSN | 0253-6269 |
Link | |
Appears in Collections | |
Registered Date |
2017-04-19 |
