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Title 

In vitro antioxidant and anti-inflammatory activities of Jaceosidin from Artemisia princeps Pampanini cv. Sajabal

Authors 

Min Jung KimJong Min HanY Y JinN I BaekM H BangH G ChungM S ChoiK T LeeD E SokTae Sook Jeong

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2008

Citation 

Archives of Pharmacal Research, vol. 31, no. 4, pp. 429-437

Keywords 

anti-inflammationantioxidantartemisia princeps pampanini cv. sajabalatherosclerosisjaceosidinmacrophagesantiinflammatory agentapolipoprotein B100immunoglobulin enhancer binding protein

Abstract 

Oxidized low-density lipoprotein (oxLDL) plays a key role in the inflammatory processes of atherosclerosis. Jaceosidin isolated from the methanolic extracts of the aerial parts of Artemisia princeps Pampanini cv. Sajabal was tested for antioxidant and anti-inflammatory activities. Jaceosidin inhibited the Cu2+-mediated LDL oxidation with IC50 values of 10.2 μM in the thiobarbituric acid-reactive substances (TBARS) assay as well as the macrophage-mediated LDL oxidation. The antioxidant activities of jaceosidin were exhibited in the conjugated diene production, relative electrophoretic mobility, and apoB-100 fragmentation on copper-mediated LDL oxidation. Jaceosidin also inhibited the generation of reactive oxygen species (ROS) concerning in regulation of NF-κB signaling. And jaceosidin inhibited nuclear factor-kappa B (NF-κB) activity, nitric oxide (NO) production, and suppressed expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-induced RAW264.7 macrophages.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-001-1175-8

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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