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Title 

Hypoxia-inducible factor-1 and nuclear factor-κB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia

Authors 

C Z WuS S HongX F CaiN T DatJ X NanB Y HwangJung Joon LeeD Lee

Publisher 

Elsevier

Issue Date 

2008

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 8, pp. 2619-2623

Keywords 

fabaceaehypoxia-inducible factor-1meroterpenoidsnuclear factor-κBpsoralea corylifolia12,13 dihydro 12,13 dihydroxybakuchiol12,13 dihydro 12,13 epoxybakuchiolacetylbakuchiolbakuchiolbisbakuchiol

Abstract 

Two new meroterpenoids, 12,13-dihydro-12,13-dihydroxybakuchiol (2) and (12′S)-bisbakuchiol C (3), were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). The structures of 2 and 3 were elucidated by spectroscopic and chemical methods. Six meroterpenoids isolated from P. corylifolia and three semi-synthetic analogues were evaluated for HIF-1 and NF-κB inhibition, and O-methyl and O-ethylbakuchiols (6 and 7) inhibited HIF-1 and NF-κB activation without significantly decreasing the viability of the AGS and HeLa cells, respectively.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2008.03.028

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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