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Title 

A diterpenoid acanthoic acid from Acanthopanax koreanum protects against D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice

Authors 

J X NanX J JinL H LianX F CaiY Z JiangH R JinJung Joon Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2008

Citation 

Biological & Pharmaceutical Bulletin, vol. 31, no. 4, pp. 738-742

Keywords 

acanthoic acidacanthopanax koreanumapoptosisfulminant hepatitistumor necrosis factor-αalanine aminotransferaseaspartate aminotransferasediterpenoidgalactosaminelipopolysaccharide

Abstract 

The hepatoprotective effects of a diterpenoid acanthoic acid isolated from Acanthopanax koreanum NAKAI were evaluated in a D-galactosamine/ lipopolysaccharide-induced fulminant hepatic failure mouse model. Mice were pretreated orally with acanthoic acid 12 and 1 h before intraperitoneal injection of D-galactosamine and lipopolysaccharide. Pretreatment with the compound markedly reduced lethal liver injury in experimental animals. The effects were likely associated with a significant decrease in serum tumor necrosis factor (TNF)-α levels, which are correlated not only with those of alanine aminotransferase and aspartate aminotransferase but also with the reduced number of apoptotic hepatocytes in the liver as confirmed using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method and DNA fragmentation assay. These results suggest that acanthoic acid protects against D-galactosamine/lipopolysaccharide-induced fulminant liver failure at least in part by a mechanism associated with the down-regulation of TNF-α secretion.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.31.738

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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