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Title 

Biosynthesis of rubradirin as an ansamycin antibiotic from Streptomyces achromogenes var. rubradiris NRRL3061

Authors 

C G KimJ LamichhaneK I SongV D NguyenD H KimT S JeongS H KangK W KimJ MaharjanYoung-Soo HongJ S KangJ C YooJung Joon LeeT J OhK LiouJ K Sohng

Publisher 

Springer Verlag (Germany)

Issue Date 

2008

Citation 

Archives of Microbiology, vol. 189, no. 5, pp. 463-473

Keywords 

ansamycinbiosynthesispolyketide synthaserubradirinrubranitrosestreptomycesansamycin derivativeantibiotic agentantibiotic resistance

Abstract 

The four overlapping cosmids from the rubradirin producer, Streptomyces achromogenes var rubradiris NRRL 3061, have 58 ORFs within a 105.6 kb fragment. These ORFs harbored essential genes responsible for the formation and attachment of four distinct moieties, along with the genes associated with regulatory, resistance, and transport functions. The PKS (rubA) and glycosyltransferase (rubG2) genes were disrupted in order to demonstrate a complete elimination of rubradirin production. The rubradirin biosynthetic pathway was proposed based on the putative functions of the gene products, the functional identification of sugar genes, and the mutant strains.

ISSN 

0003-9276

Link 

http://dx.doi.org/10.1007/s00203-007-0337-3

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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