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Title 

Suppression of inducible nitric oxide synthase and cyclooxygenase-2 expression by tussilagone from farfarae flos in BV-2 microglial cells

Authors 

H J LimHyun Sun LeeJ H Ryu

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2008

Citation 

Archives of Pharmacal Research, vol. 31, no. 5, pp. 645-652

Keywords 

cyclooxygenasefarfarae flosinhibitor kappaB-αnitric oxidenitric oxide synthasePGE 2tussilagonecyclooxygenase 2cyclooxygenase 2 inhibitorinducible nitric oxide synthase

Abstract 

Activated microglia produce diverse neurotoxic factors such as nitric oxide (NO) and prostaglandin E2 (PGE2) that may cause neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. From the EtOAc soluble fraction of Farfarae flos (Tussilago farfara), we purified tussilagone as a bioactive compound by monitoring the inhibitory potential of NO production in activated microglia through the purification procedures. Tussilagone showed dose-dependent inhibition of NO and PGE 2 production in LPS-activated microglia with IC50 values of 8.67 μM and 14.1 μM, respectively. It suppressed the expression of protein and mRNA of inducible nitric oxide synthase and cyclooxygenase-2 through the inhibition of 1-κBα degradation and nuclear translocation of p65 subunit of NF-κB. Therefore tussilagone from Farfarae flos may have therapeutic potential in the treatment of neuro-inflammatory diseases through the inhibition of overproduction of NO and PGE2.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-001-1207-4

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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